Blood is flow in vessels in liquid form. When blood is drawn from body, it thickens and forms a gel like structure. The gel is called clot. Insoluble protein fibers, i.e. fibrin trapped the elements of blood and make clot. The gel is separates from liquid, that liquid is serum and gel is clot.
Blood clotting has three stages to form a clot
Stage 1: Formation of prothrombinase enzyme by two different pathway-
Extrinic pathway
Intrinsic pathway
Stage 2: In the presence of prothrombinase enzyme and calcium, prothrombin (Clotting factor II) converts in thrombin.
Stage 3: Thrombin in the presence of calcium, converts in fibrinogen. Thrombin also activates clotting factor XIII. In the presence of Factor XIII, Fibrin threads make clot.
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| Blood Coagulation |
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