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| Causes of Jaundice |
Jaundice is yellowish discoloration of the skin, sclera and mucous membranes due to hyper bilirubinemia and deposition of bile pigments.
Some following reason develop jaundice -
Too much bilirubin being produced for the liver to remove from the blood.
For example, patients with hemolytic anemia have an abnormally rapid rate of destruction of their red blood cells that releases large amounts of bilirubin into the blood.
A defect in the liver that prevents bilirubin from being removed from the blood, converted to bilirubin/glucuronic acid (conjugated) or secreted in bile.
Blockage of the bile ducts that decreases the flow of bile and bilirubin from the liver into the intestines. For example, the bile ducts can be blocked by cancer, gallstones, or inflammation of the bile ducts. The decreased conjugation, secretion, or flow of bile that can result in jaundice is referred to as cholestasis: however, cholestasis does not always result in jaundice.
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