Thrombolytic (clot-dissolving) agents are chemical substances injected into the body that dissolve blood clots to restore circulation. They either directly or indirectly activate plasminogen. The first thrombolytic agent, approved for use in 1982, was streotokinase (kabikinase, streptase).
A more recently developed thrombolytic agent, approved in 1988 for dissolving clots in coronary arteries of the heart, is tissue plasminogen activator (t-PA). This substance, marketed under the brand name Activase, is a genetically engineered, artificial version of the natural enzyme.
It is much more expensive than streptokinase, however, and clinical trials have shown that it is not more effective.
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