MCQ on sex hormones, corticosteroids and contraceptives

1. The major natural estrogens produced by women are following, EXCEPT:

a) Estradiol (Estradiol-17β, E2)

b) Estron (E1)

c) Ethinyl estradiol

d) Estriol (E3)

Ans: (c)

2. Which of the following statements about estrogens are True:

a) Estrogens are required for normal sexual maturation and growth of the female

b) Estrogens decrease the rate of resorption of bone

c) Estrogens enhance the coagulability of blood

d) All of the above

Ans: (d)

3. The major synthetic estrogens are following, EXCEPT:

a) Dienestrol

b) Diethylstilbestrol

c) Benzestrol

d) Estradiol

Ans: (d)

4. Which of the following statements about estrogens are True:

a) Estradiol binds strongly to an α2-globulin and albumin with lower affinity

b) Estradiol is converted by liver and other tissues to estron and estriol and their 2-hydroxylated derivatives and conjugated metabolites and excreted in the bile

c) Estrone and estriol have lower affinity for the estrogen receptors than estradiol

d) All of the above

Ans: (d)

5. Indications of synthetic estrogens are following, EXCEPT:

a) Primary hypogonadism

b) Postmenopausal hormonal therapy

c) Hormonal contraception

d) For treatment of simple obesity

Ans: (d)

6. Main complications of estrogens’ therapy include the following:

a) Postmenopausal uterine bleeding

b) Breast tenderness

c) Hyperpigmentation

d) All of the above

Ans: (d)

7. Main contraindications of estrogens’ therapy include the following:

a) Estrogen-dependent neoplasmas such as carcinoma of the endometrium or carcinoma of the breast

b) Undiagnosed genital bleeding

c) Liver disease

d) All of the above

Ans: (d)

8. Tamoxifen is:

a) Antiprogestin

b) Antiandrogen

c) Antiestrogen

d) Androgen

Ans: (c)

9. Progesterone is secreted by:

a) Ovarian follicles

b) Corpus luteum

c) Granulosa and theca cells

d) All of the above

Ans: (b)

10. The major natural progestin is:

a) Estradiol

b) Estron

c) Progesterone

d) Estriol

Ans: (c)

11. Which of the following statements about progestins is True:

a) Progesterone is rapidly absorbed following administration by any route

b) In the liver, progesterone is metabolized to pregnanediol and conjugated with glucuronic acid.

c) Significant amounts of progestins and their metabolites are excreted in the urine

d) All of the above

Ans: (d)

12. The normal ovary produces small amount of androgens, including testosterone, androstenedione, and degydroepiandrosterone. This consideration is:

a) True

b) False

Ans: (a)

13. Noncontraceptive clinical uses of progestins are following:

a) Hormone replacement therapy

b) Dysmenorrhea

c) Endometriosis

d) All of the above

Ans: (d)

14. Estrogens possess immunomodulator properties, but progestins do immunodepressant ones. Is it TRUE or FALSE?

a) True

b) False

Ans: (a)

15. Mifepristone (RU-486) is:

a) Antiprogestin

b) Antiandrogen

c) Antiestrogen

d) Androgen

Ans: (a)

16. Mifepristone (RU-486) is used as a contraceptive and abortifacient. This consideration is:

a) True

b) False

Ans: (a)

17. Actions of mifepristone (RU-486) include:

a) Inhibition of ovulation during the follicular phase by blocking hypothalamic-pituitary progesterone receptors, which suppresses midcycle gonadotropin release

b) During the luteal phase, inhibition of progesterone action on the uterus, which induces prostaglandin release from the endometrium

c) Termination of pregnancy by facilitating luteolysis, menstruation, uterine motility, softening of the cervix, and detachment of the embryo.

d) All of the above

Ans: (d)

18. All of the following statements about oral contraceptives are true, EXCEPT:

a) The “combination pill” contains both estrogen and progestin

b) Ethinyl estradiol and mestranol are commonly used in oral contraceptives

c) The “minipill” contains progestin alone

d) The “triphasic pill” contains estrogen, progestin, and luteinizing hormone (LH)

Ans: (d)

 MCQ on sex hormones, corticosteroids and contraceptives