Urea produced in the liver freely diffuses and is transported in blood to kidneys, and excreted.
A small amount of urea enters the intestine where it is broken down to CO2 and NH3 by the bacterial enzyme urease. This ammonia is either lost in the feces or absorbed into the blood. In renal failure, the blood urea level is elevated (uremia), resulting in diffusion of more urea into intestine and its breakdown to NH3.
Hyperammonemia (increased blood NH3) is commonly seen in patients of kidney failure. For these patients, oral administration of antibiotics (neomycin) to kill intestinal bacteria is advised.
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| How to Dispose of urea from the body |
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