1) All of the following effects are disadvantages of anticancer drugs, EXCEPT:
a) Low selectivity to cancer cells
b) Depression of bone marrow
c) Depression of angiogenesis
d) Depression of immune system
2) Rational combination of anticancer drugs is used to:
a) Provide synergism resulting from the use of anticancer drugs with different mechanisms combination
b) Provide synergism resulting from the use of anticancer drugs with the same mechanisms combination
c) Provide stimulation of immune system
d) Provide stimulation of cell proliferation
3) Tick the anticancer alkylating drug, a derivative of chloroethylamine:
a) Methotrexate
b) Cisplatin
c) Cyclophosphamide
d) Carmustine
4) Tick the anticancer alkylating drug, a derivative of ethylenimine:
a) Mercaptopurine
b) Thiotepa
c) Chlorambucil
d) Procarbazine
5) Tick the group of hormonal drugs used for cancer treatment:
a) Mineralocorticoids and glucocorticoids
b) Glucocorticoids and gonadal hormones
c) Gonadal hormones and somatotropin
d) Insulin
6) Tick the anticancer alkylating drug, a derivative of alkylsulfonate:
a) Fluorouracil
b) Carboplatin
c) Vinblastine
d) Busulfan
7) Tick the anticancer drug of plant origin:
a) Dactinomycin
b) Vincristine
c) Methotrexate
d) Procarbazine
8) Action mechanism of alkylating agents is:
a) Producing carbonium ions altering protein structure
b) Producing carbonium ions altering DNA structure
c) Structural antagonism against purine and pyrimidine
d) Inhibition of DNA-dependent RNA synthesis
9) Tick the anticancer drug, a pyrimidine antagonist:
a) Fluorouracil
b) Mercaptopurine
c) Thioguanine
d) Methotrexate
10) Methotrexate is:
a) A purine antagonist
b) A folic acid antagonist
c) An antibiotic
d) An alkylating agent
11) Tick the antibiotic for cancer chemotherapy:
a) Cytarabine
b) Doxorubicin
c) Gentamycin
d) Etoposide
12) Fluorouracil belongs to:
a) Antibiotics
b) Antimetabolites
c) Plant alkaloids
d) Bone marrow growth factor
13) Tick the action mechanism of anticancer drugs belonging to plant alkaloids:
a) Inhibition of DNA-dependent RNA synthesis
b) Cross-linking of DNA
c) Mitotic arrest at a metaphase
d) Nonselective inhibition of aromatases
14) General contraindications for anticancer drugs are:
a) Depression of bone marrow
b) Acute infections
c) Severe hepatic and/or renal insufficiency
d) All of the above
15) Action mechanism of methotrexate is:
a) Inhibition of dihydrofolate reductase
b) Activation of cell differentiation
c) Catabolic depletion of serum asparagine
d) All of the above
16) Tick the anticancer drug belonging to inorganic metal complexes:
a) Dacarbazine
b) Cisplatin
c) Methotrexate
d) Vincristine
17) Tick the indication for estrogens in oncological practice:
a) Leukemia
b) Cancer of prostate
c) Endometrial cancer
d) Brain tumors
18) Enzyme drug used for acute leukemia treatment:
a) Dihydrofolate reductase
b) Asparaginase
c) Aromatase
d) DNA gyrase
19) All of the following drugs are derivatives of nitrosoureas, EXCEPT:
a) Carmustine
b) Vincristine
c) Lomustine
d) Semustine
20) Tick the group of drugs used as subsidiary medicines in cancer treatment:
a) Cytoprotectors
b) Bone marrow growth factors
c) Antimetastatic agents
d) All of the above
21) Tick the estrogen inhibitor:
a) Leuprolide
b) Tamoxifen
c) Flutamide
d) Anastrozole
22) Tick the antiandrogen drug:
a) Flutamide
b) Aminoglutethimide
c) Tamoxifen
d) Testosterone
23) Tick the drug belonging to aromatase inhibitors:
a) Octreotide
b) Anastrozole
c) Flutamide
d) Tamoxifen
24) Tick the drug belonging to gonadotropin-releasing hormone agonists:
a) Leuprolide
b) Tamoxifen
c) Flutamide
d) Anastrozole
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| MCQ FOR CHEMOTHERAPY OF CANCER |
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