Friday, November 16, 2018

Physiology of Pain OR Mechanism of Pain

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Prostaglandins (PGs especially PGE2 and PGI2), bradykinine and leukotrienes (LT) are pain causing chemical or stimuli. These stimuli generate pain sensation.
Prostaglandins (PGs) especially PGE2 and PGI2 sensitize afferent nerve ending to pain including mechanical and chemical stimuli. These stimuli irritate mucous membrane and produce pain. Pain is also known as algesia.   

Cell membrane phospholipid secrete arachidonic acid in the presence of phospholipase A (phospholipase A activated by chemical and mechanical stimuli).

  • Arachidonic acid in the presence of cyclooxygenase (COX enzyme), synthesize prostaglandins (PGE2, PGI2, PGD2 etc). PGE2 and PGI2 are responsible for pain sensation.
  • Arachidonic acid in the presence of lipoxygenase, synthesize leukotrienes (LT).     


Prostaglandins (PGs especially PGE2 and PGI2), bradykinine and leukotrienes (LT) are produce pain producing substance (PPS or substance P). Substance P bind with the peripheral nerve terminal and generate sensation of pain.  
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Mechanism of Pain 

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