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| Bilirubin |
Bilirubin is a yellowish pigment found in bile, a fluid made by the liver. The breakdown product of Hgb from injured RBCs and other heme containing proteins. Bilirubin produced by reticulo-endothelial system. Bilirubin released to plasma bound to albumin. Hepatocytes conjugate it and excrete through bile channels into small intestine.
Causes of increase Bilirubin
Bilirubin overproduce by reticulo-endothelial system. Bilirubin failure uptake from hepatocyte. Bilirubin failure to conjugate or excrete. Obstruction of biliary excretion into intestine.
Normal range of Bilirubin
Direct (also called conjugated) bilirubin: 0 to 0.3 mg/dL
Total bilirubin: 0.3 to 1.9 mg/dL
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